Skip to main content

Coagulation of blood (short document lecture)

                           Blood Coagulation

Definition

When blood is shed or collected in a container it loses its fluidity and becomes a jelly like mass after a few minutes. This is called clotting or the coagulation of blood.

Blood-Clot

The clot is a mesh of thin fibrils,these fibrils consist of fibrin. Fibrin is formed from Fibrinogen.
Coagulation of blood occurs through a series of reactions due to activation of group substances. These substances are necessary for clotting, called clotting factors. 13 clotting factors are identified in our body.
Factor I     Fibrinogen
Factor II    Prothrombin
Factor III   Thromboplastin (Tissue factor)
Factor IV    Calcium
Factor V     Labile factor (Proaccelerin or accelerator globulin)
Factor VI    Presence has not been proved
Factor VII   Stable factor
Factor VIII  Antihemophilic factor (Antihemophilic globulin)
Factor IX    Christmas factor
Factor X     Stuart-Prower factor
Factor XI    Plasma thromboplastin antecedent
Factor XII   Hageman factor (Contact factor)
Factor XIII  Fibrin-stabilizing factor (Fibrinase).

Sequence of clotting mechanism:

In general blood clotting occurs in three stages;
1.  Formation of prothrombin factor.
2.  Conversion of prothrombin into thrombin.
3.  Conversion of fibrinogen into fibrin.
During the process of clotting the factors which are in inactive form are converted into their active form. There is enzymatic action to produce sequence of reations.
Extrinsic Pathway & Intrinsic Pathway





Comments

  1. Factor XII (XII) (Hageman Factor) is a single chain (Mr=78,000) glycoprotein zymogen that circulates in plasma at a concentration of 40 µg/ml. Reciprical activation of XII to the active serine protease factor XIIa (XIIa) by kallikrein is central to initiation of the intrinsic coagulation p factor xiii

    ReplyDelete

Post a Comment

Popular posts from this blog

BIOPHARMACEUTICS BY LEONE SHARGEL, 7TH ED [PDF]

                                           DOWNLOAD

Precipitation-----Process of precipitation and its applications in Pharmacy.

                PRECIPITATION Supervised by;                                    Dr. Khezar Hayat Prepared by:                            Dr. Ali Mansoor                              Dr. Harry Hamid                            Dr. Abdullah Yaqoob  Precipitation Precipitation is the formation of a solid in a solution during a chemical reaction. When the chemical reaction occur the solid formed is called, precipitate. This can occur when an insoluble substance, the precipitate, is formed in the solution due to a reaction or when the solution has been supersaturated by a compound. The formation of precipitate is a sign of a chemical change. In the most situations, the solid forms out of solute phase, and sink to the bottom of solution(though it will float if it is less dense than the solvent or form suspension). Precipitate:        When the reaction occurs, the solid formed is called precipitate . Precipitant:      The agents which cause precipitation from a s

MISCELLANEOUS PROCESSES (Efflorescence, deliquescence, lyophillization, elutrition, exiccation, ignition, sublimation, fusion, calcination, adsorption, decantation, evaporation, vaporization, 27 centrifugation, dessication, levigation and trituration.)