MCQ's From Pharmaceutics I, Pharm-D

PHARMACEUTICS

PHYSICAL PHARMACY

CONTENTS

Ø PHARMACY ORIENTATION:

·        Introduction and orientation to the Profession of Pharmacy in relation to Hospital Pharmacy

·        Retail Pharmacy

·        Industrial Pharmacy

·        Forensic Pharmacy

·        Pharmaceutical education and research etc.

Ø HISTORY AND LITERATURE OF PHARMACY:

·        A survey of the history of pharmacy through ancient Greek and Arab periods with special reference to contribution of Muslim scientists to pharmacy and allied sciences.

·        An introduction of various official books.

Ø PHYSICO-CHEMICAL PRINCIPLES:

·        Solutions: Introduction, types, concentration expressions, ideal and real solution, colligative properties, their mathematical derivations and applications in pharmacy, molecular weight determinations, distribution co-efficient and its applications in pharmacy.

Ø Adsorption:

·        Techniques and processes of adsorption in detail.

Ø Hydrolysis:

·        Types and protection of products against hydrolysis

Ø Micromeritics:

·        Particle size

·        shapes and distribution of particles

·        Methods of determination of particle size and importance of particle size in Pharmacy.

Ø DISPERSIONS:

·        Colloids: Types, methods of preparation, properties (optional, kinetic, electrical). Dialysis and artificial kidney, stability of colloids, protection and sensitization phenomenon and application of colloids in Pharmacy.

·        Emulsions: Types, theories of emulsification, emulsifying agents their classification and stability of emulsion.

·        Suspensions: Type, Methods of Preparation, Properties, Suspending agents, their classification and stability.

SUBMITTED TO:-

                     Dr. KHEZAR HAYAT

SUBMITTED BY:-

                    ZEESHAN MAILK

                    HAJI MOHAMMAD

Ø PHARMACY ORIENTATION:

·        Introduction and orientation to the Profession of Pharmacy in relation to Hospital Pharmacy

1.      The study of relationship between products formulation, delivery, clinical product response and disposition is called …………………,

a.      Pharmacy    

b. physiology  

c. biochemistry  

d. pharmaceutics

ANS: d because it is a definition.

2.      The profession in which medication are prepared, dispensed and information regarding products provided to the public and healthcare professions is known as…………, 

a .Pharmaceutics  

b. physiology  

c. pharmacy 

 d. pharmacology.

ANS: c because it is definition.

3.      A person who is education in [Pharm D] and licensed to dispense products to patient with appropriate instruction is known as …………….

a. Pharmacist 

b. physiologist 

c. pharmacologist 

d. scientist. 

ANS: a because it is a definition.

4.      What does pharmacy practices is involves…….

a. Review and interpretation of prescription  

b.  suggestion of new prescription  

c. none  

d. both.

ANS: a is correct because it helps us to confirm the correctness of prescription.

5.      Nuclear pharmacy is used to produce products which are used for…….

a.      surgical  

b.  diagnostic 

c.  Heart disease  

d. All of these.

ANS: b is correct it trace a specific element which causes disease.

6.      Pharmacy is the………………,

a.      Art  

b. science 

c. both

 d. none .

ANS:c is correct because medicine formula is scientific and naming etc is art.

7.      The entry level degree in pharmacy is………..,

a.DVM  

b.  pharmD  

c.  M phil  

d. None of these.

ANS: b is correct because it is a professional and educational combination.

8.      At industrial level pharmacists are involved in……..,

a.       Marketing and sales 

b. administration

c. both  

d. None

ANS: c is correct because at industrial level both of the above skills are needed to promote the sales of industry.

9.      Which of following is not one of the areas of study in pharmacy……..?

a.      Pharmaceutics 

b.  industrial pharmacy .

c pharmacology 

d. None of these.

ANS: d is correct because all of above are the areas of study in pharmacy.

What does community pharmacy involve………

a)      Professional skills

b)     Management ability

c)      Both a and b

d)     None of these

ANS: c is correct because it also tells us about marketing of products. which involve both of these.

Pharmacy practice in private and government hospital is called………

a)      Health system pharmacy

b)     Community pharmacy

c)      Both of these

d)     None of these

ANS: a is correct because in hospital we does not have concern with marketing.

In industrial pharmacy pharmacists are involved in …………

a)      Marketing and sales

b)     Administration

c)      Both of these

d)     None of these

ANS: a is correct because in industrial pharmacy we have not to confirm the correctness of prescription.

Ø  HISTORY AND LITERATURE OF PHARMACY

Ø .Micromeritics:

10.                       It is a branch of science which deals with the study of smaller particles and determination of their size by using advanced method and technology is known as…………,

a.     diffusion  b.esterification  c.  Microorganisms  d.  Micromeritics.

ANS: d is correct because it is  the definition of micromeritics.

·        Particle size

11. Micromeritics is the study of …………..?

a.       Big particles  

b.  small particles  

c.  both  

d.  None of these.

ANS: b is correct 

12.          The size and surface area of a particles in ………….?

a.      Physical  

b.  chemical  

c.  Pharmacologic properties of products  

d.  All of these.

ANS: d is correct.

13.          Particle size of product can affect its release from dosage forms administered orally by……..?

a.      Medically  

b.  Clinically  

c.both  

d.  None of these.

ANS: b is correct.

14.             Frequency distribution curve is obtained when

a.      Number of particles is plotted against the mean size range

b.      Mean size range is plotted against the number of particles

c.       Number of particles and the mean size are on x-axis

d.      both  a and b

ANS: a&b is correct because the curve is obtained when number of particles and mean size range is against each-other.

15.   Methods for determining particle size include ;

a)      Optical microscopy

b)      Sieving

c)       Sedimentation

d)      All of these

ANS: d is correct because all of the above mentioned methods are used for determining the particle size.

16.   Ordinary microscope can measure the particle size between range

a) 0.2 to 100 m

b) 0.2 to 100 mm

c) 0.2 to 100 µm

d) 0.2 to 100 nm

ANS: c is correct because it is defined range of microscope

17.   The size of particle is measured by microscope with the help of

a)      Eye-piece

b)      Micro-meter

c)       Eye-piece fitted with micro-meter

d)      None

ANS: c is correct because the size is measured by the combined working of eye-piece and micro-meter.

18.   Sieving method uses a series of standard sieves calibrated by the………..

a)      National Bureau of standards

b)      IUPAC

c)       Any of these

d)      None

ANS: a is correct because NBS controls the standards

19.   Order of sieves in sieving is ……….

a)      Coarse,moderately coarse, moderately fine, fine, very fine

b)      Moderately coarse, coarse, moderately fine, fine, very fine

c)       Moderately coarse, coarse, fine, moderately fine, very fine

d)      Coarse, moderately coarse, fine, moderately fine, very fine

ANS: a is correct because the order of sieving is from coarse to very fine

20.   Sieving errors can arise by factors including………..

a)      Sieve loading & duration

b)      Intensity of agitation

c)       A & b

d)      None

ANS: c is correct because these both errors are often present during sieving

21.   The particle size in sub sieve range can be found by gravity sedimentation as expressed in…..

a)      Van’t hoff factor

b)      Ohm’s law

c)       Stoke’s law

d)      Graham’s law

ANS:c is correct because Stoke’s law gives the information of particle movement under the action of gravity while others are not related to it.

22.   Andreasen Apparatus works under the principle of

a)      Microscopy

b)      Sedimentation

c)       Sieving

d)      All of above

ANS: b is correct because Andreasen apparatus is used to carry-out sedimentation.

23.   Any instrument used for measuring volume of particle is……..

a)      Andreasen apparatus

b)      Coulter counter

c)       Fisher sub sieveseizer

d)      None

ANS: b is correct because coulter counter gives the volume of particle while Andreasen and fisher doesn’t give the volume of particle

24.   Granulators are used for ……….,

a)      Making particles longitudinal

b)      Cuboidal  

c)       Spherical

d)      Elliptical

ANS: c is correct because granulators are used to make granules which are spherical.

25.   A sphere has…………,

a)      Maximum surface area 

b)      Minimum

c)       Normal

d)      None of these

ANS: b is correct

26.   The specific surface is the ……….

a)      surface area per unit volume

b)      surface area per unit weight

c)       both a and b

d)      none of these

ANS: c is correct because specific surface is taken for the both volume and the weight.

27.   Methods for determining surface area are

a)      Absorption method

b)      Adsorption method

c)       Air permeability method

d)       b & c

ANS: d is correct because both methods are used for determining the surface area of the particle.

28.   The adsorbed layer in adsorption method is monomolecular at

a)      Very low pressure

b)      Low pressure

c)       High pressure

d)      Very high pressure

ANS: b is correct because it is an experimental proof.

29.   The adsorbed layer in adsorption method is multimolecular at

a)      Very low pressures

b)      Low pressures

c)       Higher pressures

d)      All of above

ANS: c is correct because it is an experimental proof.

30.   An instrument used to calculate the surface area of particles is…………….

a)      Quantasorb QS-16

b)      Quanta-adsorb QD-16

c)       Boyton apparatus

d)      Quanta-apparatus

ANS:a is correct because Quntasorb is used for the calculation of surface area and it also can be used to calculate the pore structure of pharmaceutical powder.

31.   In adsorption method the particle whose surface area is to be measured is taken as…..

a)      Adsorbate

b)      Adsorbent

c)       Any of above

d)      Both of above

B is correct because the surface area of adsorbent is measured in adsorption method.

DISPERSIONS(colloids):

32.   Particle size of colloids ………….,

a)      1 nm to 0.5µm

b)      1 µm to 0.5mm

c)       1 mm to 0.5m

d)      1 m to 0.5mm

ANS: a is correct because it is the determined value.

33.   The process which it consisted of at least two phases with one or more disperse phase in a single dispersion medium is called..........

a)      Disperse phase

b)      Dispersion medium

c)       Dispersion

d)      All of these

ANS: c is correct because it is a definition.

34.   The distinct homogeneous part of system separated by definite boundariesfrom other parts of the system is known as..........

a)      Phase

b)      Pro phase

c)       Ana phase

d)      Solution

ANS: a is correct because it is a definition.

35.   How many types of dispersion.........?

a)      1

b)      2

c)       3

d)      4

ANS: c is correct becausedispersion has three types molecular dispersion, colloidal dispersion, coarse dispersion.

36.   Molecular dispersion ranges from.........

a)      1 to 500nm

b)      ‹1nm

c)       ‹500nm

d)      None of these

ANS: b is correct because this dispersion depends upon the size of molecules and molecules are very least in size even less than 1 nm.

37.   The increasing trend of diameter is..........

a)      Molecular dispersion,colloidal dispersion, coarse dispersion.

b)      Colloidal dispersion, coarse dispersion, molecular dispersion.

c)       Corse dispersion, molecular dispersion, colloidal dispersion.

d)      All of these

ANS: a is correct because diameter increases from molecular to coarse dispersion.

38.   The decreasing trend of diameter is..........

a)      Coarse dispersion, molecular dispersion, colloidal dispersion.

b)      Coarse dispersion, colloidal dispersion, molecular dispersion.

c)       Molecular dispersion coarse dispersion colloidal dispersion.

d)      None of these

ANS: b is correct because diameter decreases from coarse to molecular dispersion.

39.   The dispersion medium in blood is.........

a)plate lets

b)      serum

c)    plasma

d)      oxygen

ANS: c is correct.

40.   The best example of all dispersion is..........

a)      oxygen

b)      blood

c)       proteins

d)      all of these

ANS: b is correct because it has particles of all size ranges.

41.   Blood is composed of..........

a)      proteins

b)      peptide

c)       glucose

d)      all of these

ANS: d is correct because it contains hormones, haemoglobin and glucose.

42.   Molecular dispersion easily passes through.........

a)      electron microscope

b)      ultra filtration

c)       filter paper

d)      all of these

ANS: d is correct because it has very least particle size.

43.   No diffusion takes place in...........

a)      molecular dispersion

b)      colloidal dispersion

c)       coarse dispersion

d)      none of these

ANS: c is correct because it has very large particle size

44.   Osmoses cannot formed when particles are in......

a)      equilibrium state

b)      random state

c)       both a and b

d)      none of these

ANS: a is correct because it is movement according to concentration gradient and at equilibrium there is no net concentration gradient.

45.   Microscopic particles can be separated by..........

a)      ultra filtration

b)      filtration

c)       dialysis

d)      all of above

ANS: b is correct because filter paper has less pore size than that of microscopic particles.

46.   Colloids are …………,

a)      can’t be observed by ordinary microscope

b)      detected under ultra microscope

c)       both a and b

d)      none

ANS: c is correct because ordinary microscope has less resolving power than that of ultra-microscope

47.   Colloids can pass through ……..?

a)      filter paper

b)      semi-permeable membrane

c)       both a and b

d)      none

ANS: a is correct because it has lesser particle size as compared to the size of pores in the filter paper.

48.   Colloids can’t pass through ………

a)      filter paper

b)      Semi-permeable

c)       Both a and b

d)      None of these

ANS: b is correct because it selectively allows particles to pass through it.

49.   Diffusion of colloids is……….

a)      Very slow

b)      Slow

c)       Fast

d)      Very fast

ANS: a is correct because it has greater particle size and particles diffuse slowly.

50.   Cheese is an example of ………….

a)      Molecular dispersion

b)      Colloidal

c)       Coarse

d)      All of above

ANS: b is correct because particle size in cheese lies in the colloidal range.

51.   Example of colloidal dispersion is……..

a)      oxygen molecules

b)      milk

c)       none

d)      all

ANS: b is correct because milk particle size lies in the range of colloids.

52.   …………. Is not an example of colloidal dispersion

a)      cheese

b)      milk

c)       synthetic polymers

d)      RBC’s

ANS: d is correct because its paricle size lies in the range of coarse dispersion.

53.   Scattering of light form colloidal particles is ………..

a)      faraday Tyndall effect

b)      van’t hoff factor

c)       van’t hoff dispersion

d)      none

e)      ANS: a is correct because faraday Tyndall effect explains the scattering of light in the colloids while van’t hoff factor & dispersion are not related to scattering of light.

54.   Faraday Tyndall effect is observed by………

a)      light microscopy

b)      Ultramicroscope

c)       Radiography

d)      None

ANS: b is correct because light microscope has less resolving power and radiography has not much efficiency in this regard while ultra-microscope is mostly used.

55.   Who invented ultra microscope………..

a)      Zsigmonday

b)      Faraday

c)       Tyndall

d)      Ohm

ANS: a is correct because he is the inventor of the ultra-microscope.

56.   As a result of Tyndall effect………..

a)      dark spots

b)      bright spots are formed

c)       both a and b

d)      any of a and b

ANS: b is correct because bright spots are formed against black background .

57.   The process in which dispersed phase is mix in a suitable solvent the process is known as……….

a)      Salvation

b)      Dehydration

c)       Hydration

d)      All of these

ANS: a is correct because it results in the preparation of solution and process is called solvation.

58.   The instrument which is use to reduce the particle size is called………

a)      Size reduction

b)      Milling

c)       Mold

d)      All of above

ANS: b is correct because milling instruments make particle spherical and with lesser particle size.

59.   The process in which we converted coarse particles into colloidal then it is called

a)      Milling

b)      Size reduction

c)       Size oxidation

d)      None of these

ANS: b is correct because particle size of coarse dispersions is reduced to colloidal particles.

60.   Any type of chemical compound that posses two distinct regions that is hydrophilic and hydrophobic portion within same molecule is called……….

a)      Amphiphyllic

b)      Electrophyle

c)       Both a and b

d)      None of these

ANS: a is correct because amphiphyllic is a term used to show both types of portions in a molecule.

61.   Amphiphyllics are also called……

a)      Association colloidal

b)      Surface active agents

c)       Amphipathics

d)      All of above

ANS: d is correct because all are synonyms

62.   Inter phase is composed of   ………..

a)      Water phase

b)      Air phase

c)       Both a and b

d)      None of these

ANS: c is correct because it is a term.

63.   The large phase is called……….

a)      Inter phase

b)      Bulk phase

c)       Both a and b

d)      None of these

ANS: b is correct because in a container the more quantity shows bulk.

64.   The point at which bulk phase and air, water inter phase become saturated is called………

a)      CMC

b)      Bulk phase

c)       Inter phase

d)      None of these

ANS: a is correct because in a container air, water inter phase and bulk phase are at equilibrium state.

65.   It is an aggregation of surfactant molecule in a colloidal liquid then it is called ………….

a)      CMC

b)      Micelles

c)       Aggregation number

d)      None of these

ANS: b is correct because it is a definition.

66.   Dispersed phase and dispersion medium of smoke are………….

a)      solid and liquid

b)      liquid and liquid

c)       solid and gas

d)      gas and gas

ANS: c is correct because smoke is consists of solid particles dispersed in gas phase

67.   Margarine is a colloidal system of

a)      foam

b)      emulsion

c)       aerosol

d)      solid emulsion

ANS: 

68.   Light scattering in colloidal system is known as

a)      Brownian motion

b)      Faraday-Tyndal effect

c)       Coagulation

d)      Electrophoresis

ANS: b is correct because light scattering in colloids due to particles in the system which is explained by faraday-Tyndal effect

69.     Which of the following is not a colloidal property………

a)      Composed of two phases

b)      Stable

c)       Homogenous

d)      Can be filtered

ANS:

Adsorption;

70.   Adsorption is the process of ……….

a)      Repulsion

b)      Addition

c)       Adhesion

d)      None of these

ANS: c is correct because atoms, ions or molecules show adhesion to a specific surface.

71.   Surface on which ions, atoms or molecules accumulate

a)      Adsorbent

b)      Adsorbate

c)       Specific surface

d)      All

ANS: a is correct because the surface on which ions accumulate is called adsorbent.

72.   Adsorbate are ions, atoms or molecules

a)      Which allow accumulation on their surface

b)      Which accumulate on a specific surface

c)       Which don’t accumulate

d)      Both

ANS: b is correct because these are the molecules which accumulate on a specific surface during the process of adsorption.

73.   If both adsorption & absorption are going side by side then it is……….

a)      Disorption

b)      Desorption

c)       Sorption

d)      Resorption

ANS: c is correct because sorption is the process in which both of the above stated processes go side by side.

74.   Reverse of adsorption is called

a)      Disorption

b)      Desorption

c)       Sorption

d)      Resorption

ANS: b is correct because reverse of adsorption is desorption which results in separation of adsorbent and adsorbate.

75.   Vander-wall adsorption is synonym of………….

a)      Physical adsorption

b)      Chemical adsorption

c)       Physi-adsorption

d)      a& c

ANS: d is correct because both are the names of vander-wall adsorption

76.   Physi-adsorption is effected by

a)      Temperature only

b)      Pressure only

c)       Temperature and pressure

d)      None

ANS: c is correct because it is experimental conditions.

77.   Strong bonding is present in

a)      Chemical adsorption

b)      Physical adsorption

c)       Vander-wall adsorption

d)      a&c

ANS: a is correct becaue only chemical adsorption involves strong bonding.

78.   Absorption is …………….. phenomenon

a)      Bulk

b)      Surface

c)       Phase difference

d)      Bulk & phase

ANS: a is correct because it occurs through-out the bulk of system.

79.   Adsorption  has

a)      Uniformity

b)      Non-uniformity

c)       Bulk uniformity

d)      a & c

ANS: b is correct because it is only the surface phenomenon.

80.   Temperature and pressure can

a)      Effect absorption

b)      Can’t effect absorption

c)       Can effect adsorption

d)      b & c

ANS: d is correct because it effects adsorption but not effect absorption.

81.   Chemical adsorption involves ……. Bonding

a)      Hydrogen

b)      Ionic

c)       Covalent

d)      Ionic & covalent

ANS: b is correct because it involves strong ionic bonding

82.   Chemical adsorption is

a)      Reversible

b)      Irreversible

c)       Mostly reversible

d)      Some-times irreversible

ANS: b is correct because it is irreversible.